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PRODUCT

ATF System

XCell® ATF Systems attach to a bioreactor to intensify
upstream manufacturing capacity, productivity, and throughput.

INTENSIFICATION DELIVERS MORE PRODUCT FASTER

XCell ATF Technology helps simplify and intensify upstream processes to deliver more product, faster. Intensified processes achieve higher cell densities,
require smaller bioreactors and consume less suite time. Increase throughput, productivity, and capacity in both clinical and commercial manufacturing.

HOW XCell ATF® TECHNOLOGY WORKS

The XCell ATF System is based on award-winning alternating tangential flow (ATF) technology, created by the action of a diaphragm moving upward and downward within a pump head, connected to a filter housing and attached to a bioreactor. Alternating tangential flow is attained by the action of a diaphragm pump.

XCell ATF® LAB DEVIES

The XCell ATF System simplifies and fast-tracks upstream intensification development from PD to commercial scale. Intensification increases throughput, accelerates tech transfer and optimizes your process in clinical manufacturing and MSAT while increasing bioreactor productivity and reducing costs in commercial manufacturing. Higher productivity, smaller bioreactors and higher throughput with shorter times to harvest, combine to mitigate facility expansion risks and capital costs.

XCell™ Lab System

Designed and engineered as a complete solution, the XCell™ Lab System integrates devices, controller and software,
enabling low volume process intensification ready for scale-up.

  • Engineering-designed controller promotes increased intensification
  • Configurable set-up delivers high throughput - a single manifold supports up to 8 XCell ATF Devices
  • Software enables precise technical control with a user-friendly interface
  • New XCell ATF 1 Device is fit for low volume intensification ready for scale-up
  • Repligen global technical support ensures successful implementation and scale-up

XCell® LS Controller for Pilot and Commercial Manufacturing​

Scaling up from bench scale to commercial scale can be simple with a reliable controller for vital cGMP operations

  • Pairs with single-use and stainless steel XCell ATF 6 and XCell ATF 10 devices, and the stainless steel XCell ATF 4 device​
  • Single LS Controller controls single or dual ATF devices at once​
  • Advanced process monitoring: flow sensor-based control, permeate pressure sensing/filter fouling​
  • Intuitive software with touchscreen interface, 21 CFR part 11 compliant, and Windows 10 Domain security​
  • Operate independently with HMI or integrate with site DCS systems (headless configuration)​
  • Global technical support ensures successful implementation and scale-up

DESIGNED AND ENGINEERED AS A COMPLETE SOLUTION

  • 1Flow sensor
  • 2XCell ATF® filtration device
  • 3XCell™ Lab controller and software
  • 4Supply air protection assembly(SAPA)
  • 5Vacuum manifold
  • 6Vacuum pump

5TH GENERATION CONTROLLER WITH PRECISION ENGINEERING

The XCell™ Lab controller is engineered for robust intensification and user-friendly experience.

  • Maintain precise flow rates even at high viscosities during the late stages of intensification development using a control logic loop with re-engineered hardware.
  • Monitor real-time filter status using a recording of permeate pressure data.
  • Configure alarms for key process events at just the right moment, reducing errors and maximizing efficiency.
  • Visualize key trending data on a tablet-based graphical interface designed for clarity makesthe system enjoyable to use.
  • Increase productivity by deploying up to two filtration devices that can be configured on either one bioreactor or two.

XCell ATF® LAB DEVIES

  • XCell ATF® 1 Device (SU)
    0.5~2L

  • XCell ATF® 2 Device (SU,SS)
    2~10L

  • XCell ATF® 4 Device (SS)
    10~50L

XCell ATF® DEVICES AND CONTROLLERS

The XCell ATF System delivers a complete solution for upstream intensification with robust hardware software integration. Available in single-use and stainless steel formats with sizes from lab-scale (2 L) to process scale (5000 L). Each system consists of an XCell ATF  Device, XCell Controller, software, tubing and sensors.

XCell® ATF Devices and Controllers

XCell® ATF Systems simplify and fast-track upstream intensification by providing an integrated solution consisting of an XCell® ATF Device, XCell® ATF Controller, software, tubing, pressure sensors and accessories. The family of Systems supports diverse applications across development from 1L to 5000 L.

XCell ATF® Device Size Selection Guide

Presented are hollow fiber filter areas, XCell® ATF Pump volumes, and typical bioreactor working volumes paired with each XCell ATF Device.
Actual capacity and vessel size depend upon specific cell culture process conditions.

Device Effective filter surface area(㎡) Approximate ATF volume exchanged (L) Suspension cultures volume(L)
XCellATF 1 0.022 0.017 0.5~2
XCellATF 2 0.13 0.1 2~10
XCellATF 4 0.77 0.4 10~50
XCellATF 6 2.5 1.3 50~200
XCellATF 10 11.0 6.0 200~1000

XCell ATF® Single-use Devices

  • XCell ATF® 1 Single-use Device

  • XCell ATF® 2 Single-use Device

  • XCell ATF® 6 Single-use Device

  • XCell ATF® 10 Single-use Device

XCell ATF® Single-use Tubing Sets

XCell ATF® Stainless Steel Devices

  • XCell ATF® 2 Stainless Steel Device

  • XCell ATF® 4 Stainless Steel Device

  • XCell ATF® 6 Stainless Steel Device

  • XCell ATF® 10 Stainless Steel Device

XCell™ Controller

  • XCell™ Lab Controller

    • for use with:
    • XCell ATF 1(SU)
    • XCell ATF 2(SU,SS)
    • XCell ATF 4(SS)

  • XCell LS Controller

    • for use with:
    • XCell ATF 4(SS)
    • XCell ATF 6(SU,SS)
    • XCell ATF 10(SU,SS)

  • XCell ATF® C410 Controller

    • for use with:
    • XCell ATF 4(SS)
    • XCell ATF 6(SU,SS)
    • XCell ATF 10(SU,SS)
    • XCell C410 Controller Cart (optional)

XCell ATF® devices by scale

XCell ATF® 1 XCell ATF® 2 XCell ATF® 4 XCell ATF® 6 XCell ATF® 10
Typical Bioreactor size(L) 0.5~2 2~10 10~50 50~200 200~5000
Format SU SU,SS SS SU,SS SU,SS
Chemistry PES PES, PS PES, PS PES, PS PES, PS
Typical pore size SU 0.2μ 0.2μ 0.2μ 0.2μ 0.2μ
Typical pore size SS NA 0.2μ, 0.5μ, 50kDa 0.2μ, 0.5μ, 50kDa 0.2μ, 0.5μ, 50kDa 0.2μ, 0.5μ, 50kDa
Effective surface area(㎡) 0.022 0.13 0.77 2.5 11
Filter height(㎝) 60 60 30 60 60
Displacement volume(L) 0.017 0.1 0.4 1.3 6
ATF flow range(Lpm) 0.008~0.140 0.4~1.5 3~8 10~20 30~80
Typical scalable flow/fiber And filtrate rate 12 ㎖/min/fiber and 4~6LMH
Controller Xcell Lab Scale Controller • XCell Lab Scale Controller
• XCell C410 Controller
• XCell LS Controller 		• XCell C410 Controller
• XCell LS Controller 		• XCell C410 Controller
• XCell LS Controller