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PRODUCT

KrosFlo® KR2i TFF System

Single-use fully integrated benchtop TFF system for use in lab scale process development ranging from 2mL - 15L. Compatible with hollow fiber or flat sheet filters, this system offers many user-defined set-point controls so you can run complex applications in fully-automated modes.

Modularity Made Easy with Plug-and-Play Configurability

KrosFlo® KR2i TFF systems achieve an unparalleled combination of configurability and user-simplicity through modular, plug-and-play hardware. All components, either directly or indirectly, connect to the main pump, which then communicates with the KF Comm 2 software for control and monitoring.

More Capabilities, Still Simple

Get more out of TFF with the flexibility to configure your system to better suit your application needs. Keep your process compact and minimal or expand your capabilities to more advance modes of operation by adding components. Switch back and forth between configurations all without compromising on ease of use.

Mode C D, CD, CDC, CFC CFC/D/C, CDDC, CDCD
Capability Process Data Pressure, Flowrate, feed weight Pressure, Flowrate, Permeate and Feed weight Pressure, Flowrate, Permeate and Feed weight, Conductivity, temperature, UV
TMP control √ √ √
Set up & walk-away automation √ √ √
Single-interface monitoring and control √ √ √
Component Example 1 Example 2 Example 3
KF Comm 2 Software ● ● ●
Base pump ● ● ●
Feed Scale ● ● ●
Back pressure control valve ● ● ●
Permaeate Scale ● ●
Auxiliary pump1 ● ●
Auxiliary pump2 ●
Konduit (UV, conductivity, temperature sensors) ●

System features at a glance

The fully integrated KrosFlo KR2i TFF System features a digital peristaltic pump, graphical LCD display, digital pressure monitor, KR2i Pump head, automatic backpressure valve, filter module stand, and KF Comm real-time data collection software. Highly configurable and versatile, the KrosFlo KR2i utilizes a number user-defined set-points to run complex application processes with numerous built-in safety alarms and stops. The system can run up to two stackable pump heads for higher flow rates.

Effortless scaling with a single standardized platform

Designed as a platform and not as standalone units, KrosFlo KR2i, and KMPi TFF systems share the same components, software and controls across the entire family,
allowing you to confidently standardize your process. Common process change challenges during scale-up are removed.

THE FIRST TIME IS
THE RIGHT TIME WITH
THE KrosFlo® KR2iR
TFF SYSTEM

KrosFlo® KR2i TFF System Product Components

1. AUTOMATIC BACK PRESSURE CONTROL VALVE

A Repligen-exclusive technology, the Automatic Back Pressure Control Valve adds transmembrane pressure (TMP) control to every TFF process, reducing operator hands-on-time and improving process reproducibility.

  • Automatically adjust tubing pinch distance according to user-defined set-points
  • Maintain uniform TMP throughout process run, decreasing membrane fouling
  • Control permeate pressure and flow during microfiltration applications
  • Use with compatible tubing sizes 13, 14, 16, 25, HP15, 17, HP24, 18, HP35, 36, and HP36
  • Activate automatically using inlet, retentate, permeate or transmembrane pressures

2. MENU-DRIVEN SOFTWARE FOR OPTIMIZED TFF

KF Comm 2 Software, backward compatible with legacy KrosFlo® KR2i and KrosFlo® KMPi Systems, is conveniently installed on any computer using the Windows Operating System. The software is compatible with Chrome, Mozilla, Firefox and Microsoft Explorer browsers and is always current with automatic software and firmware updates.

  • Proprietary software optimized for KrosFlo® TFF Systems
  • Validated for GMP Processes with optional 21 CFR Part 11 option
  • Intuitive workflow with 13 modes of operation

KrosFlo® KR2i TFF System Accessories

1. CONFIGURABLE ProConnex® FLOW PATH

Enhanced through an engineering design process, ProConnex® Flow Paths are customized, configurable and complete assemblies for tangential flow filtration. Designed for use with hollow fiber and/or flat sheet TFF systems, the assemblies are sterile, fit for upstream or downstream processing and manufactured in compliance with ISO guidelines in an ISO 7 clean room.

2. KONDUIT ADD-ON MONITOR

Konduit is an add-on module ready to use with the KrosFlo® KR2i and KMPi TFF Systems, with the ability to scale from 2mL to 500L process volumes.

Konduit adds:
  • End point conductivity control for UF /DF
  • End point UV control for diafiltering free drug from drug delivery particles
  • End point UV control for concentration of certain molecules
  • UV alarm for membrane breakthrough
  • A260 and A280 light sources available