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PRODUCT

KrosFlo® KMPi TFF System

Fully automate 100 ml - 500 L UF/DF processes using an unparalleled
combination of hardware integration with peristaltic pump, configurability and
automation through modular, plug-and-play hardware.

Concentrate with a streamlined configuration

The KrosFlo® KMPi TFF System achieves an unparalleled combination of integration, configurability and automation through modular, plug-and-play hardware. All components, either directly or indirectly, connect to the main KrosFlo® KMPi peristaltic pump, which then communicates with the KF Comm 2 software for control and monitoring.

  • Configure a minimal number of components for simple applications such as concentration (C) or diafiltration (D)
  • Plug-and-play additional components for fractionation (F) and multi-step processes (i.e. CDC/D/C)
Mode C D, CD, CDC, CFC CFC/D/C, CDDC, CDCD
Capability Process Data Pressure, Flowrate,
Permeate weight 		Pressure, Flowrate, Permeate and Feed weight Pressure, Flowrate, Permeate and Feed weight, Conductivity, temperature, UV
Automation + ++ ++++
Component Example 1 Example 2 Example 3
KF Comm 2 Software √ √ √
KMPi Peristaltic Pump √ √ √
Feed Scale √ √ √
Back pressure control valve √ √ √
Permaeate Scale √ √ √
KR1 peristaltic pump √ √
KR1 peristaltic Pump2 √
Konduit √
Sensors (conductivity, temperature, UV) √

  • Concentrate with a streamlined
    configuration

  • Add a scale and auxiliary pump to access
    diafiltration applications

  • Build process understanding with
    increased sensors

KrosFlo® KMPi TFF System

The fully integrated KrosFlo® KMPi TFF System consists of hardware, software and flow path components. Key hardware components include: a digital peristaltic pump, auxiliary pumps and an automatic back pressure valve. The KF Comm 2 software features a multi-language interface for complete monitoring and control and an optional 21 CFR Part 11 environment. Add tubing and sanitize/sterilize your own flow path around a Spectrum® hollow fiber filter or build a closed and gamma-irradiated ProConnex® Flow Path from over 250 components.

KrosFlo®  KMPi TFF System Product Components

1. AUTOMATIC BACK PRESSURE CONTROL VALVE

A Repligen-exclusive technology, the Automatic Back Pressure Control Valve adds transmembrane pressure (TMP) control to every TFF process, reducing operator hands-on-time and improving process reproducibility.

  • Automatically adjust tubing pinch distance according to user-defined set-points
  • Maintain uniform TMP throughout process run, decreasing membrane fouling
  • Control permeate pressure and flow during microfiltration applications
  • Use with compatible tubing sizes 13, 14, 16, 25, HP15, 17, HP24, 18, HP35, 36, and HP36
  • Activate automatically using inlet, retentate, permeate or transmembrane pressures

2. MENU-DRIVEN SOFTWARE FOR OPTIMIZED TFF

KF Comm 2 Software, backward compatible with legacy KrosFlo® KR2i and KrosFlo® KMPi Systems, is conveniently installed on any computer using the Windows Operating System. The software is compatible with Chrome, Mozilla, Firefox and Microsoft Explorer browsers and is always current with automatic software and firmware updates.

  • Proprietary software optimized for KrosFlo® TFF Systems
  • Validated for GMP Processes with optional 21 CFR Part 11 option
  • Intuitive workflow with 13 modes of operation

KrosFlo®  KMPi TFF System Accessories

1. CONFIGURABLE ProConnex® FLOW PATH

Enhanced through an engineering design process, ProConnex® Flow Paths are customized, configurable and complete assemblies for tangential flow filtration. Designed for use with hollow fiber and/or flat sheet TFF systems, the assemblies are sterile, fit for upstream or downstream processing and manufactured in compliance with ISO guidelines in an ISO 7 clean room.

2. KONDUIT ADD-ON MONITOR

Konduit is an add-on module ready to use with the KrosFlo® KR2i and KMPi TFF Systems, with the ability to scale from 2mL to 500L process volumes.

Konduit adds:
  • End point conductivity control for UF /DF
  • End point UV control for diafiltering free drug from drug delivery particles
  • End point UV control for concentration of certain molecules
  • UV alarm for membrane breakthrough
  • A260 and A280 light sources available